Green Dye Beats Blue for Node Mapping in Uterine Cancer A green fluorescent dye beat the standard blue dye for mapping lymph nodes when the two were compared directly in women with uterine or cervical cancers. The finding comes from a phase 3 noninferiority trial, known as Fluorescence Imaging for Lymphatic Mapping (FILM). The results showed not only that indocyanine green fluorescent dye was noninferior to isosulfan blue dye when used in conjunction with near-infrared imaging but also that it was significantly better than the standard-issue blue dye in identifying more sentinel nodes and more lymph nodes with metastases in women with uterine cancers. The study was published online August 21 in the Lancet Oncology. "Accurate identification of sentinel lymph nodes in patients with cancer improves detection of metastatic disease and decreases surgical morbidity, " Michael Frumovitz, MD, University of Texas MD Anderson Cancer Center, Houston, and colleagues write. "If [indocyanine green fluorescent dye] is approved for on-label use, it will hopefully become the new standard of care for lymphatic mapping and sentinel lymph node biopsy for women with cervical and uterine cancers, " they suggest. "Through its user-friendliness and effectiveness, indocyanine green is enabling surgeons to transition from systematic lymphadenectomy to sentinel lymph node biopsy, " the editorialists suggest. The findings from this study "confirm both the non-inferiority and superiority of indocyanine green compared with isosulfan blue dye as a new standard in sentinel lymph node mapping,
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